Appropriate Pneumococcal Vaccination in Infants in Fiji

Grant number: 2 U01 AI052337-04 (Revised)

Abstract

DESCRIPTION (provided by applicant): The Fiji Pneumococcal Project that has been funded by NIH has been designed to provide all the information necessary to facilitate the early introduction of infant pneumococcal immunization into Fiji, a small developing country in the Pacific. The project has evaluated the burden of pneumonia, otitis media and pneumococcal meningitis in Fijian infants. This information, along with the results of a new study of the outcome of pneumococcal meningitis that is included with this application, will be used to build the economic argument for pneumococcal immunization. The vaccine trial will evaluate the impact of one, two or three doses of pneumococcal conjugate..

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Related publications (9)

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Impaired serotype-specific immune function following pneumococcal vaccination in infants with prior carriage

PV Licciardi, FM Russell, A Balloch, RL Burton, MH Nahm, G Gilbert, MLK Tang, EK Mulholland

2014-04-25

The impact of prior nasopharyngeal carriage on serotype-specific IgG responses following immunization with pneumococcal conjugate ..

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Pneumococcal polysaccharide vaccine at 12 months of age produces functional immune responses

PV Licciardi, A Balloch, FM Russell, RL Burton, J Lin, MH Nahm, EK Mulholland, MLK Tang

2012-01-01

Background: Infections with Streptococcus pneumoniae (pneumococcus) are a cause of significant child mortality. Pneumococcal glyco..

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Serotype-specific avidity is achieved following a single dose of the 7-valent pneumococcal conjugate vaccine, and is enhanced by 23-valent pneumococcal polysaccharide booster at 12 months

FM Russell, A Balloch, PV Licciardi, JR Carapetis, L Tikoduadua, L Waqatakirewa, YB Cheung, EK Mulholland, MLK Tang

2011-06-15

Aim: To evaluate whether the avidity of serotype-specific IgG to pneumococcal serotypes is enhanced by an increased number of dose..

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Opsonophagocytic activity following a reduced dose 7-valent pneumococcal conjugate vaccine infant primary series and 23-valent pneumococcal polysaccharide vaccine at 12 months of age

FM Russell, JR Carapetis, RL Burton, J Lin, PV Licciardi, A Balloch, L Tikoduadua, L Waqatakirewa, YB Cheung, MLK Tang, MH Nahm, EK Mulholland

2011-01-10

Opsonophagocytic activity (OPA) was measured following reduced infant doses of 7-valent pneumococcal conjugate vaccine (PCV-7) wit..

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Antibodies to serotype 9V exhibit novel serogroup cross-reactivity following infant pneumococcal immunization

PV Licciardi, A Balloch, FM Russell, EK Mulholland, MLK Tang

2010-05-14

Cross-reactivity within the pneumococcal immune response was examined in this study. Significant cross-reactivity between serotype..

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Hyporesponsiveness to re-challenge dose following pneumococcal polysaccharide vaccine at 12 months of age, a randomized controlled trial

FM Russell, JR Carapetis, A Balloch, PV Licciardi, AWJ Jenney, L Tikoduadua, L Waqatakirewa, J Pryor, J Nelson, GB Byrnes, YB Cheung, MLK Tang, EK Mulholland

2010-04-26

Background: To evaluate the immunological impact of the 23-valent pneumococcal polysaccharide vaccine (23vPPS) at 12 months, for c..

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Safety and immunogenicity of the 23-valent pneumococcal polysaccharide vaccine at 12 months of age, following one, two, or three doses of the 7-valent pneumococcal conjugate vaccine in infancy

FM Russell, PV Licciardi, A Balloch, V Biaukula, L Tikoduadua, JR Carapetis, J Nelson, AWJ Jenney, L Waqatakirewa, S Colquhoun, YB Cheung, MLK Tang, EK Mulholland

2010-04-19

Fijian infants aged 6 weeks were stratified by ethnicity and randomized to receive 0, 1, 2, or 3 PCV-7 doses with or without the 2..

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Infants aged 12 months can mount adequate serotype-specific IgG responses to pneumococcal polysaccharide vaccine

A Balloch, PV Licciardi, FM Russell, EK Mulholland, MLK Tang

2010-01-01

This is the first study examining serotype-specific IgG responses following immunization with the polysaccharide vaccine Pneumovax..

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Immunogenicity following one, two, or three doses of the 7-valent pneumococcal conjugate vaccine

FM Russell, A Balloch, MLK Tang, JR Carapetis, P Licciardi, J Nelson, AWJ Jenney, L Tikoduadua, L Waqatakirewa, J Pryor, GB Byrnes, YB Cheung, EK Mulholland

2009-09-18

The aim was to identify an appropriate infant pneumococcal vaccination strategy for resource poor countries. Fijian infants receiv..

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